Open AccessThe prp4 kinase gene and related spliceosome factor genes in Trichophyton rubrum respond to nutrients and antifungals
Author(s) -
Tamires Aparecida Bitencourt,
Felipe Beraldo de Oliveira,
Pablo Rodrigo Sanches,
Antônio Rossi,
Nilce M. Martinez-Rossi
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000967
Subject(s) - trichophyton rubrum , biology , gene , spliceosome , protein kinase a , in silico , fungal protein , genetics , rna splicing , microbiology and biotechnology , kinase , saccharomyces cerevisiae , rna , antifungal
Trichophyton rubrum is a dermatophyte that causes most human superficial mycoses worldwide. The spliceosome, a large ribonucleoprotein complex responsible for pre-mRNA processing, may confer adaptive advantages to deal with different stresses. Here, we assessed the structural aspects of the Prp4 kinase protein and other pre-mRNA-splicing factors (Prps) in T. rubrum grown in different protein sources and exposed to antifungal drugs.