The prp4 kinase gene and related spliceosome factor genes in Trichophyton rubrum respond to nutrients and antifungals | Zendy

Tamires A. Bitencourt | Zendy; Felipe Beraldo de Oliveira | Zendy; Pablo Rodrigo Sanches | Zendy; Antônio Rossi | Zendy; Nilce Maria Martinez-Rossi | Zendy

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The prp4 kinase gene and related spliceosome factor genes in Trichophyton rubrum respond to nutrients and antifungals

Author(s) -

Tamires A. Bitencourt,

Felipe Beraldo de Oliveira,

Pablo Rodrigo Sanches,

Antônio Rossi,

Nilce Maria Martinez-Rossi

Publication year - 2019

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000967

Subject(s) - trichophyton rubrum , biology , gene , spliceosome , protein kinase a , in silico , fungal protein , genetics , rna splicing , microbiology and biotechnology , kinase , saccharomyces cerevisiae , rna , antifungal

Trichophyton rubrum is a dermatophyte that causes most human superficial mycoses worldwide. The spliceosome, a large ribonucleoprotein complex responsible for pre-mRNA processing, may confer adaptive advantages to deal with different stresses. Here, we assessed the structural aspects of the Prp4 kinase protein and other pre-mRNA-splicing factors (Prps) in T. rubrum grown in different protein sources and exposed to antifungal drugs.

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