Open AccessRespiratory syncytial virus promoted the differentiation of Th17 cells in airway microenvironment through activation of Notch-1/Delta3
Author(s) -
Ling Qin,
Kezi Qiu,
Chengping Hu,
Lili Wang,
Guojun Wu,
Ousman Bajinka
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000959
Subject(s) - jag1 , notch signaling pathway , lung , biology , immunology , western blot , virus , notch 1 , respiratory system , cellular differentiation , virology , medicine , microbiology and biotechnology , signal transduction , gene , anatomy , genetics
Respiratory syncytial virus (RSV) infection is associated with serious lung disease in infants and immunocompromised individuals and is linked to development of asthma. Infection of RSV has been shown to induce Th lymphocyte differentiation. The present study was designed to determine the effects of RSV on the expression of Notch-1 and the related mechanisms on subsequent differentiation of Th lymphocytes.