Open AccessHeat-treated Lactobacillus plantarum increases the immune responses through activation of natural killer cells and macrophages on in vivo and in vitro models
Author(s) -
PhilDong Moon,
Jin Soo Lee,
Hee-Yun Kim,
Ning Han,
Inyeong Kang,
Hyung-Min Kim,
HyunJa Jeong
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000938
Subject(s) - immune system , interleukin 12 , tumor necrosis factor alpha , biology , in vivo , immunology , innate immune system , natural killer cell , microbiology and biotechnology , in vitro , cytotoxicity , cytotoxic t cell , biochemistry
Recently, Lactobacillus plantarum (nF1) has been reported to have immune-enhancing effects in an immunosuppressed-animal model. Natural killer (NK) cells and macrophages play important roles in the immune responses. However, immunomodulatory effects of heat-treated Lactobacillus plantarum-nF1 (hLp-nF1) on the activation of NK cells and macrophages have not been elucidated.