Open AccessThe effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
Author(s) -
Amy E. Bryant,
Sumiko Gomi,
Eva J. Katahira,
David B. Huang,
Dennis L. Stevens
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000929
Subject(s) - nafcillin , staphylococcus aureus , methicillin resistant staphylococcus aureus , microbiology and biotechnology , vancomycin , toxin , antibacterial agent , trimethoprim , biology , antibiotics , bacteria , penicillin , genetics
Extracellular protein toxins contribute to the pathogenesis of Staphylococcus aureus infections. The present study compared the effects of iclaprim and trimethoprim - two folic acid synthesis inhibitors - with nafcillin and vancomycin on production of Panton-Valentine leukocidin (PVL), alpha haemolysin (AH) and toxic-shock syndrome toxin I (TSST-1) in methicillin-resistant and vancomycin-intermediate S. aureus (MRSA and VISA, respectively).