The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus | Zendy

Amy E. Bryant | Zendy; Sumiko Gomi | Zendy; Eva J. Katahira | Zendy; David B. Huang | Zendy; Dennis L. Stevens | Zendy

Open Access

The effects of iclaprim on exotoxin production in methicillin-resistant and vancomycin-intermediate Staphylococcus aureus

Author(s) -

Amy E. Bryant,

Sumiko Gomi,

Eva J. Katahira,

David B. Huang,

Dennis L. Stevens

Publication year - 2019

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000929

Subject(s) - nafcillin , staphylococcus aureus , methicillin resistant staphylococcus aureus , microbiology and biotechnology , vancomycin , toxin , antibacterial agent , trimethoprim , biology , antibiotics , bacteria , penicillin , genetics

Extracellular protein toxins contribute to the pathogenesis of Staphylococcus aureus infections. The present study compared the effects of iclaprim and trimethoprim - two folic acid synthesis inhibitors - with nafcillin and vancomycin on production of Panton-Valentine leukocidin (PVL), alpha haemolysin (AH) and toxic-shock syndrome toxin I (TSST-1) in methicillin-resistant and vancomycin-intermediate S. aureus (MRSA and VISA, respectively).

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