Open AccessExamining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection
Author(s) -
Tim J. Sloan,
James Turton,
Jess Tyson,
Alison Musgrove,
Vicki M. Fleming,
Michelle M. Lister,
Matthew Loose,
R. Elizabeth Sockett,
Mathew Diggle,
Frances Game,
William Jeffcoate
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000907
Subject(s) - microbiome , diabetic foot , biology , metagenomics , diabetic foot ulcer , microbiology and biotechnology , ecology , diabetes mellitus , bioinformatics , genetics , gene , endocrinology
While some micro-organisms, such as Staphylococcus aureus, are clearly implicated in causing tissue damage in diabetic foot ulcers (DFUs), our knowledge of the contribution of the entire microbiome to clinical outcomes is limited. We profiled the microbiome of a longitudinal sample series of 28 people with diabetes and DFUs of the heel in an attempt to better characterize the relationship between healing, infection and the microbiome.