Open AccessSubinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus
Author(s) -
Eva J. Katahira,
Stephen M. Davidson,
Dennis L. Stevens,
Devin D. Bolz
Publication year - 2019
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000905
Subject(s) - staphylococcus aureus , leukocidin , microbiology and biotechnology , toxin , exotoxin , linezolid , nafcillin , methicillin resistant staphylococcus aureus , antibiotics , panton–valentine leukocidin , hemolysin , biology , chemistry , vancomycin , bacteria , penicillin , virulence , biochemistry , genetics , gene
Potent extracellular toxins including alpha-haemolysin, Panton-Valentine leukocidin (PVL) and toxic-shock syndrome toxin 1 (TSST-1) significantly contribute to Staphylococcus aureus pathogenesis, thus, toxin suppression is a primary focus in treatment of staphylococcal disease. S. aureus maintains complex strategies to regulate toxin expression and previous data have demonstrated that subinhibitory concentrations of beta-lactam antibiotics can adversely increase S. aureus exotoxin production. The current study evaluates the effects of subinhibitory concentrations of tedizolid, a second-generation oxazolidinone derivative, on expression of staphylococcal exotoxins in both methicillin-resistant and methicillin-sensitive S. aureus.