Subinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus | Zendy

Eva J. Katahira | Zendy; Stephen M. Davidson | Zendy; Dennis L. Stevens | Zendy; Devin D. Bolz | Zendy

Open Access

Subinhibitory concentrations of tedizolid potently inhibit extracellular toxin production by methicillin-sensitive and methicillin-resistant Staphylococcus aureus

Author(s) -

Eva J. Katahira,

Stephen M. Davidson,

Dennis L. Stevens,

Devin D. Bolz

Publication year - 2018

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000905

Subject(s) - staphylococcus aureus , leukocidin , microbiology and biotechnology , toxin , exotoxin , linezolid , nafcillin , methicillin resistant staphylococcus aureus , antibiotics , panton–valentine leukocidin , hemolysin , biology , chemistry , vancomycin , bacteria , penicillin , virulence , biochemistry , genetics , gene

Potent extracellular toxins including alpha-haemolysin, Panton-Valentine leukocidin (PVL) and toxic-shock syndrome toxin 1 (TSST-1) significantly contribute to Staphylococcus aureus pathogenesis, thus, toxin suppression is a primary focus in treatment of staphylococcal disease. S. aureus maintains complex strategies to regulate toxin expression and previous data have demonstrated that subinhibitory concentrations of beta-lactam antibiotics can adversely increase S. aureus exotoxin production. The current study evaluates the effects of subinhibitory concentrations of tedizolid, a second-generation oxazolidinone derivative, on expression of staphylococcal exotoxins in both methicillin-resistant and methicillin-sensitive S. aureus.

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