A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 β-lactamase | Zendy

Kohei Uechi | Zendy; Tatsuya Tada | Zendy; Yusuke Sawachi | Zendy; Tomomi Hishinuma | Zendy; Rei Takaesu | Zendy; Mika Nakama | Zendy; Isamu Nakasone | Zendy; Teruo Kirikae | Zendy; Jiro Fujita | Zendy

Open Access

A carbapenem-resistant clinical isolate of Aeromonas hydrophila in Japan harbouring an acquired gene encoding GES-24 β-lactamase

Author(s) -

Kohei Uechi,

Tatsuya Tada,

Yusuke Sawachi,

Tomomi Hishinuma,

Rei Takaesu,

Mika Nakama,

Isamu Nakasone,

Teruo Kirikae,

Jiro Fujita

Publication year - 2018

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000842

Subject(s) - meropenem , aeromonas hydrophila , imipenem , microbiology and biotechnology , aeromonas , carbapenem , biology , recombinant dna , gene , tetr , bacteria , antibiotics , antibiotic resistance , genetics , repressor , transcription factor

Several species of Aeromonas produce the enzyme CphA metallo-β-lactamase. This study describes an isolate of Aeromonas hydrophila harbouring an acquired gene encoding the carbapenemase GES-24. This isolate was obtained from an inpatient in Okinawa, Japan, with no apparent record of travelling overseas. The minimum inhibitory concentrations of carbapenems against this isolate were 8 µg ml -1 for imipenem and 16 µg ml -1 for meropenem. Recombinant GES-24 hydrolyzed all of the tested β-lactams, including imipenem and meropenem. The genomic environment surrounding blaGES-24 was intI1-blaGES-24-aac(6')-IIc-qacEdelta1-sulI-orfX-tetR-tetE. This is the first report of A. hydrophila producing a GES-type carbapenemase.

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