Open AccessGluconeogenic growth of Vibrio cholerae is important for competing with host gut microbiota
Author(s) -
Jipeng Wang,
Xiaolin Xing,
Xiaoman Yang,
I-Ji Jung,
Guijuan Hao,
Yaran Chen,
Ming Liu,
Hui Wang,
Jun Zhu
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000828
Subject(s) - vibrio cholerae , biology , microbiology and biotechnology , colonization , gluconeogenesis , pathogen , cholera , gut flora , bacteria , metabolism , immunology , biochemistry , genetics
The gastrointestinal tract is home to thousands of commensal bacterial species. Therefore, competition for nutrients is paramount for successful bacterial pathogen invasion of intestinal ecosystems. The human pathogen Vibrio cholerae, the causative agent of the severe diarrhoeal disease, cholera, is able to colonize the small intestine, which is protected by mucus. However, it is unclear which metabolic pathways or nutrients V. cholerae utilizes during intestinal colonization and growth.