Open AccessPasteurella multocida inactivated with ferric chloride and adjuvanted with bacterial DNA is a potent and efficacious vaccine in Balb/c mice
Author(s) -
Maryam Homayoon,
Yahya Tahamtan,
Mohammad Kargar,
Seyed Mohammad Hossein Hosseini,
Abbas Akhavan Sepahy
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000794
Subject(s) - pasteurella multocida , bdna test , adjuvant , immune system , immunity , fowl cholera , humoral immunity , inactivated vaccine , biology , immunization , virology , microbiology and biotechnology , vaccination , antibody , immunology , virus , bacteria , hepatitis c virus , genetics
Pasteurella multocida (P. multocida) is a principal pathogen of domestic animals and an opportunistic pathogen of humans. It is the causative agent of pneumonia and haemorrhagic septicaemia in cattle, sheep and goats, fowl cholera in chickens and progressive atrophic rhinitis in swine. In this study, we investigated the humoral and cellular immune responses and protective immunity conferred by an iron-inactivated vaccine with bacterial DNA (IIV+bDNA) as an adjuvant in mice.