A clinical isolate of Escherichia coli co-harbouring mcr-1 and bla NDM-5 in Japan | Zendy

Hiroki Uchida | Zendy; Tatsuya Tada | Zendy; Yoshie Sugahara | Zendy; Akira Kato | Zendy; Isao Miyairi | Zendy; Teruo Kirikae | Zendy

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A clinical isolate of Escherichia coli co-harbouring mcr-1 and bla NDM-5 in Japan

Author(s) -

Hiroki Uchida,

Tatsuya Tada,

Yoshie Sugahara,

Akira Kato,

Isao Miyairi,

Teruo Kirikae

Publication year - 2018

Publication title -

journal of medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.91

H-Index - 117

eISSN - 1473-5644

pISSN - 0022-2615

DOI - 10.1099/jmm.0.000793

Subject(s) - escherichia coli , microbiology and biotechnology , enterobacteriaceae , biology , genetics , gene

The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and blaNDM-5 genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and blaNDM-5.

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