Open AccessA clinical isolate of Escherichia coli co-harbouring mcr-1 and bla NDM-5 in Japan
Author(s) -
Hiroki Uchida,
Tatsuya Tada,
Yoshie Sugahara,
Akira Kato,
Isao Miyairi,
Teruo Kirikae
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000793
Subject(s) - escherichia coli , microbiology and biotechnology , enterobacteriaceae , biology , genetics , gene
The mcr-1 gene encodes a phosphoethanolamine transferase, which confers resistance to colistin by transferring phosphoethanolamine to lipid A. This study describes the emergence of a colistin- and carbapenem-resistant clinical isolate of Escherichia coli harbouring mcr-1 and blaNDM-5 genes, located on 90 and 150 Kb plasmids, respectively. The isolate belonged to ST132. This is the first report of a clinical isolate in Japan co-harbouring mcr-1 and blaNDM-5.