Open AccessASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa
Author(s) -
Ami Hughes,
Claire A. Knoten,
Alexander Morris,
Alan R. Hauser
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000782
Subject(s) - pseudomonas aeruginosa , pneumonia , microbiology and biotechnology , medicine , immunology , biology , bacteria , genetics
Pseudomonas aeruginosa expresses a type III secretion system (T3SS) that activates the host inflammasome-mediated immune response. We examined the role of inflammasome activation in severe infection outcomes.