Open AccessOuter-membrane protein LptD (PA0595) plays a role in the regulation of alginate synthesis in Pseudomonas aeruginosa
Author(s) -
Sundar Pandey,
Camila Delgado,
Hansi Kumari,
Laura Flórez,
Kalai Mathee
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000752
Subject(s) - pseudomonas aeruginosa , bacterial outer membrane , microbiology and biotechnology , pseudomonadales , pseudomonas , bacteria , pseudomonadaceae , chemistry , biology , biochemistry , escherichia coli , genetics , gene
The presence of alginate-overproducing (Alg + ) strains of Pseudomonas aeruginosa in cystic fibrosis patients is indicative of chronic infection. The Alg + phenotype is generally due to a mutation in the mucA gene, encoding an innermembrane protein that sequesters AlgT/U, the alginate-specific sigma factor. AlgT/U release from the anti-sigma factor MucA is orchestrated via a complex cascade called regulated intramembrane proteolysis. The goal of this study is to identify new players involved in the regulation of alginate production.