Open AccessMolecular characterization and antifungal susceptibility testing of Cryptococcus neoformans sensu stricto from southern Brazil
Author(s) -
Patricia Fernanda Herkert,
Jacques F. Meis,
Gabriel Lucca de Oliveira Salvador,
Renata Rodrigues Gomes,
Vânia A. Vicente,
Marisol Dominguez Muro,
Russo Pinheiro,
Arnaldo Lopes Colombo,
Alexandre Vargas Schwarzbold,
Carla Sakuma de Oliveira,
Marcelo Simão Ferreira,
Flávio QueirozTelles,
Ferry Hagen
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000698
Subject(s) - cryptococcus neoformans , biology , cryptococcosis , amplified fragment length polymorphism , cryptococcus , population , genotype , microbiology and biotechnology , cryptococcus gattii , microsatellite , genetic diversity , genetics , allele , medicine , environmental health , gene
Cryptococcosis is acquired from the environment by the inhalation of Cryptococcus cells and may establish from an asymptomatic latent infection into pneumonia or meningoencephalitis. The genetic diversity of a Cryptococcus neoformans species complex has been investigated by several molecular tools, such as multi-locus sequence typing, amplified fragment length polymorphism (AFLP), restriction fragment length polymorphism and microsatellite analysis. This study aimed to investigate the genotype distributions and antifungal susceptibility profiles of C. neoformans sensu lato isolates from southern Brazil.