Open AccessThe double adjuvants LTB and CpG significantly enhanced the immuno-protective effects of recombinant GIT derived from Staphylococcus aureus and Streptococcus in mice
Author(s) -
Jingyun Ma,
Liquan Yu,
Baifen Song,
Yao Yu,
Shaoduo Zhang,
Yuhua Wei,
Zhijun Wu,
Di Yao,
Wenjin Yu,
Zhu Zhang,
Yudong Cui
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000666
Subject(s) - cpg oligodeoxynucleotide , adjuvant , immunogenicity , biology , microbiology and biotechnology , antigen , antibody , cpg site , enterotoxin , immune system , immunization , immunology , gene expression , gene , escherichia coli , dna methylation , biochemistry
In this study, we prepared GapC1-150-IsdB126-361-TRAP (GIT) proteins plus heat-labile enterotoxin B (LTB) as an intra-molecular adjuvant, together with CpG to further enhance its immunogenicity.