Open AccessActinobacillus pleuropneumoniae culture supernatant antiviral effect against porcine reproductive and respiratory syndrome virus occurs prior to the viral genome replication and transcription through actin depolymerization
Author(s) -
Yenney Hernandez Reyes,
Chantale Provost,
Carolina Kist Traesel,
Mario Jacques,
Carl A. Gag
Publication year - 2018
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/jmm.0.000659
Subject(s) - porcine reproductive and respiratory syndrome virus , biology , virology , western blot , cell culture , viral replication , immunofluorescence , microbiology and biotechnology , porcine circovirus , actinobacillus pleuropneumoniae , virus , antibody , gene , serotype , immunology , biochemistry , genetics
Recently, the strong antiviral activity of an Actinobacillus pleuropneumoniae (App) culture supernatant against porcine reproductive and respiratory syndrome virus (PRRSV) was discovered. Following this finding, the objective of the present study was to understand how the App culture supernatant inhibits PRRSV replication in its natural targeted host cells, i.e. porcine alveolar macrophages (PAMs).