Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19 | Zendy

Molly K. Roe | Zendy; Nathan A. Junod | Zendy; Audrey R. Young | Zendy; Dia C. Beachboard | Zendy; Christopher C. Stobart | Zendy

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Targeting novel structural and functional features of coronavirus protease nsp5 (3CLpro, Mpro) in the age of COVID-19

Author(s) -

Molly K. Roe,

Nathan A. Junod,

Audrey R. Young,

Dia C. Beachboard,

Christopher C. Stobart

Publication year - 2021

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/jgv.0.001558

Subject(s) - polyproteins , protease , coronavirus , biology , virology , covid-19 , coronaviridae , computational biology , enzyme , medicine , biochemistry , infectious disease (medical specialty) , disease , pathology , outbreak

Coronavirus protease nsp5 (M pro , 3CL pro ) remains a primary target for coronavirus therapeutics due to its indispensable and conserved role in the proteolytic processing of the viral replicase polyproteins. In this review, we discuss the diversity of known coronaviruses, the role of nsp5 in coronavirus biology, and the structure and function of this protease across the diversity of known coronaviruses, and evaluate past and present efforts to develop inhibitors to the nsp5 protease with a particular emphasis on new and mostly unexplored potential targets of inhibition. With the recent emergence of pandemic SARS-CoV-2, this review provides novel and potentially innovative strategies and directions to develop effective therapeutics against the coronavirus protease nsp5.

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