Open AccessLong-term stability of antibody responses elicited by Dengue virus envelope DIII-based DNA vaccines
Author(s) -
J Slon-Campos,
Monica Poggianella,
Óscar R. Burrone
Publication year - 2018
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/jgv.0.001094
Subject(s) - virology , dengue vaccine , neutralizing antibody , biology , dengue virus , dna vaccination , antibody , antibody dependent enhancement , avidity , dengue fever , immunization , virus , serotype , vaccination , immunology
Dengue virus (DENV) is one the most important viral pathogens worldwide. Currently there is an imperative need for a reliable vaccine capable of inducing durable protection against all four serotypes. We have previously reported strongly neutralizing and highly specific antibody responses from all four serotypes to a DNA vaccine based on an engineered version of DENV E protein's domain III (DIII). Here, we show that monovalent and tetravalent immunizations with the DIII-based DNA vaccines are also capable of inducing highly stable antibody responses that remain strongly neutralizing over long periods of time. Our results demonstrate that DNA-vaccinated mice maintain a strong antibody response in terms of titre, avidity and virus-neutralizing capability 1 year after immunization.