Open AccessMutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
Author(s) -
Héctor Ricardo Morbidoni,
Agustina I. de la Iglesia,
Virginia Figueroa,
Cecilia Beatriz Di Capua,
Thomas R. Ioerger,
Tanya Parish
Publication year - 2019
Publication title -
access microbiology
Language(s) - English
Resource type - Journals
ISSN - 2516-8290
DOI - 10.1099/acmi.0.000070
Subject(s) - econazole , mycobacterium smegmatis , clotrimazole , mycobacterium tuberculosis , azole , mutant , microbiology and biotechnology , biology , gene , medicine , genetics , tuberculosis , antifungal , miconazole , pathology
Azole drugs such as econazole, are active onMycobacterium tuberculosisandMycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmp L5- mmp S5 conferred resistance to econazole inM. tuberculosis . We herein report that an azole-resistant mutant screen inM. smegmatisrendered mutations in rsh A, encoding a non-essential anti-sigma H protein.