Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis | Zendy

Héctor R. Morbidoni | Zendy; Agustina I. de la Iglesia | Zendy; Virginia Figueroa | Zendy; Cecilia Beatriz Di Capua | Zendy; Thomas R. Ioerger | Zendy; Tanya Parish | Zendy

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Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Author(s) -

Héctor R. Morbidoni,

Agustina I. de la Iglesia,

Virginia Figueroa,

Cecilia Beatriz Di Capua,

Thomas R. Ioerger,

Tanya Parish

Publication year - 2019

Publication title -

access microbiology

Language(s) - English

Resource type - Journals

ISSN - 2516-8290

DOI - 10.1099/acmi.0.000070

Subject(s) - econazole , mycobacterium smegmatis , clotrimazole , mycobacterium tuberculosis , azole , mutant , microbiology and biotechnology , biology , gene , medicine , genetics , tuberculosis , antifungal , miconazole , pathology

Azole drugs such as econazole, are active onMycobacterium tuberculosisandMycobacterium smegmatis ; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmp L5- mmp S5 conferred resistance to econazole inM. tuberculosis . We herein report that an azole-resistant mutant screen inM. smegmatisrendered mutations in rsh A, encoding a non-essential anti-sigma H protein.

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