Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis | Zendy

Matthew B. McNeil | Zendy; Somsundaram Chettiar | Zendy; Divya Awasthi | Zendy; Tanya Parish | Zendy

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Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis

Author(s) -

Matthew B. McNeil,

Somsundaram Chettiar,

Divya Awasthi,

Tanya Parish

Publication year - 2019

Publication title -

access microbiology

Language(s) - English

Resource type - Journals

ISSN - 2516-8290

DOI - 10.1099/acmi.0.000006

Subject(s) - rifampicin , mycobacterium tuberculosis , tuberculosis , pharmacology , drug , cell , microbiology and biotechnology , chemistry , conjugate , medicine , biology , biochemistry , pathology , mathematical analysis , mathematics

There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.

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