Open AccessCell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis
Author(s) -
Matthew B. McNeil,
Somsundaram Chettiar,
Divya Awasthi,
Tanya Parish
Publication year - 2019
Publication title -
access microbiology
Language(s) - English
Resource type - Journals
ISSN - 2516-8290
DOI - 10.1099/acmi.0.000006
Subject(s) - rifampicin , mycobacterium tuberculosis , tuberculosis , pharmacology , drug , cell , microbiology and biotechnology , chemistry , conjugate , medicine , biology , biochemistry , pathology , mathematical analysis , mathematics
There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.