Open AccessRole of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species
Author(s) -
R. Gupta,
Sandeep Gupta,
Nirmal Kumar Ganguly
Publication year - 1997
Publication title -
journal of medical microbiology/journal of medical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.91
H-Index - 117
eISSN - 1473-5644
pISSN - 0022-2615
DOI - 10.1099/00222615-46-5-403
Subject(s) - pathogenesis , fimbria , escherichia coli , microbiology and biotechnology , reactive oxygen species , biology , respiratory burst , enterobacteriaceae , mutant , immunology , biochemistry , gene
The role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis was studied for two Escherichia coli strains. Although both strains produced a similar total oxidative burst of chemiluminescence in macrophages from uninfected mice, the extracellular oxidative burst was greater with the non-fimbriate mutant E. coli BH-5 than its type-1 fimbriate parent E. coli 31-B. Moreover, macrophages from mice infected with the non-fimbriate mutant gave a much greater oxidative burst when stimulated with latex particles than that given by macrophages from mice infected with the type-1 fimbriate parent. These results correlated with the degree of renal inflammation and scarring as measured by malondialdehyde formation. Hence, the role of type-1 fimbriae in the pathogenesis of chronic UTI although documented does not appear to be significant.