Open AccessFosfomycin-resistance Plasmids Determine an Intracellular Modification of Fosfomycin
Author(s) -
Javier León,
Juan M. Garcı́a-Lobo,
Jesús Navas,
José M. Ortiz
Publication year - 1985
Publication title -
microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 179
eISSN - 1465-2080
pISSN - 1350-0872
DOI - 10.1099/00221287-131-7-1649
Subject(s) - fosfomycin , escherichia coli , plasmid , microbiology and biotechnology , chemistry , cytoplasm , intracellular , antibiotics , incubation , biology , biochemistry , dna , gene
Escherichia coli cells carrying fosfomycin-resistance plasmids modify fosfomycin intracellularly. The product of this modification (fosfomycin-derivative) differs from fosfomycin in chromatographic mobility, but the chemical nature of the modification is not yet known. Fosfomycin-derivative appears to have a cytoplasmic location and lacks antibiotic activity. The modification system can be saturated by an excess of fosfomycin in the incubation media.