Open AccessUptake of 3,4-Dihydroxy[3H]phenylalanine by Mycobacterium leprae Isolated from Frozen (-80 0C) Armadillo Tissue
Author(s) -
Saroj R. Khanolkar,
E. J. Ambrose,
P. R. Mahadevan
Publication year - 1981
Publication title -
microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 179
eISSN - 1465-2080
pISSN - 1350-0872
DOI - 10.1099/00221287-127-2-385
Subject(s) - armadillo , mycobacterium leprae , dihydroxyphenylalanine , mycobacterium , phenylalanine , microbiology and biotechnology , biology , biochemistry , chemistry , bacteria , leprosy , amino acid , immunology , genetics , neuroscience , dopamine
Mycobacterium leprae separated from armadillo tissues stored at -80 degrees C is similar to that from human sources in its ability to take up 3H-labelled 3,4-dihydroxyphenylalanine (DOPA). Several inhibitors were studied which showed complete or partial inhibition of [3H]DOPA uptake. These findings suggest that M. leprae isolated from frozen tissue possesses an active uptake system for [3H]DOPA.