Open AccessA novel hepatitis C virus (HCV) subtype from Somalia and its classification into HCV clade 3
Author(s) -
Karim Abid,
Rafael Quadri,
AnneLise Veuthey,
Antoine Hadengue,
Francesco Negro
Publication year - 2000
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-81-6-1485
Subject(s) - clade , biology , virology , hepatitis c virus , phylogenetic tree , genotype , hepacivirus , virus , flaviviridae , interferon , genetics , gene
Hepatitis C virus (HCV) sequences from throughout the world have been grouped into six clades, based on recently proposed criteria. Here, the partial sequences and clade assignment are reported for three HCV isolates from chronic hepatitis C patients from Somalia, for whom conventional assays failed to identify the genotype. Phylogenetic analysis of the sequences of the core, envelope 1 and part of the non- structural 5b regions suggests that all three isolates belong to a distinct HCV genetic group, tentatively classified as subtype 3h. This novel HCV subtype shows the highest sequence similarity with HCV isolates from Indonesia. Despite the fact that these patients were infected with HCV clade 3, none of them responded to standard interferon treatment.