Open AccessAnalysis of bovine herpesvirus 4 genomic regions located outside the conserved gammaherpesvirus gene blocks
Author(s) -
Patrick Lomonte,
Michel Bublot,
Vickyl . vAN Santen,
Günther M. Keil,
Paul-Pierre Pastoret,
Étienne Thiry
Publication year - 1995
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-76-7-1835
Subject(s) - biology , virology , gene , bovine herpesvirus 1 , conserved sequence , genetics , herpesviridae , virus , base sequence , viral disease
Bovine herpesvirus 4 (BHV-4) DNA sequences located outside the gene blocks conserved among the gammaherpesviruses BHV-4, herpesvirus saimiri (HVS) and Epstein-Barr virus (EBV) were analysed. Twelve potential open reading frames (ORFs) were found. Protein database comparisons showed that no ORF translation products were similar to proteins encoded by alpha- or betaherpesviruses. Nevertheless, six of the ORFs were homologous in amino acid sequences to proteins encoded by HVS but apparently not to those encoded by EBV. Furthermore, the location and orientation of these six ORFs in the BHV-4 genome were similar to the corresponding ORFs in the HVS genome. No genes homologous to known cellular genes were found in the BHV-4 genome; this feature is the major difference between the BHV-4 and HVS genomes with regards to the overall gene content.