Open AccessMolecular epidemiology of foot-and-mouth disease virus type O
Author(s) -
Juan-Carlos Saiz,
Francisco SánchezMadrid,
Joaquı́n Dopazo
Publication year - 1993
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-74-10-2281
Subject(s) - biology , foot and mouth disease virus , phylogenetic tree , virology , virus , molecular epidemiology , phylogenetics , foot and mouth disease , genetics , gene , genotype
A phylogenetic tree based on the VPI sequences of type O foot-and-mouth disease virus (FMDV) has been derived. Direct sequencing of PCR products has been used to obtain the VP1 gene sequences of new isolates. The tree exhibits four main lineages that largely correlate with the geographical origin of isolates. The analysis supports a close relationship between European O1 field isolates and vaccine strains, with the exception of O Thalheim Aus/81 and O Wuppertal Ger/82 which were probably of non-European origin. Analysis of nucleotide substitutions indicates that synonymous mutations play a major role in FMDV evolution.