Open AccessOpen reading frames 1 and 2 of adenovirus region E4 are conserved between human serotypes 2 and 5
Author(s) -
Ian Dix,
Keith N. Leppard
Publication year - 1992
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-73-11-2975
Subject(s) - orfs , biology , open reading frame , virology , serotype , genetics , rna splicing , sequence (biology) , nucleic acid sequence , encode , peptide sequence , gene , rna
The E4 region of human adenovirus type 2 is predicted to encode seven proteins as judged from its nucleotide sequence and the pattern of differential splicing of its transcript. Two of the open reading frames (ORFs), ORF1 and ORF2, had been identified as being disrupted in the recently published sequence of the related serotype 5 virus. These ORFs were resequenced and found to be intact in the wt300 strain of adenovirus type 5.