Open AccessA 28 000 Molecular Weight Human Cytomegalovirus Structural Polypeptide Studied by means of a Specific Monoclonal Antibody
Author(s) -
Maria Carla Re,
Maria Paola Landini,
P. Coppolecchia,
G. Furlini,
M. La Plaça
Publication year - 1985
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-66-11-2507
Subject(s) - virology , monoclonal antibody , biology , cytomegalovirus , human cytomegalovirus , antibody , immunology , virus , herpesviridae , viral disease
We have produced a monoclonal antibody against human cytomegalovirus (HCMV) which recognizes a structural protein of 28 000 mol. wt. which is present in both the cytoplasm of infected cells during the late phase of the viral replication cycle and in the extracellular viral particles. This antigen was detected in all HCMV strains assayed and reacted with human sera having anti-HCMV antibodies.