Open AccessThe Role of Liver in the Catabolism of Human - and beta-Interferon
Author(s) -
Velio Bocci,
A. Pacini,
L. Bandinelli,
G. P. Pessina,
Michela Muscettola,
Luana Paulesu
Publication year - 1982
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-60-2-397
Subject(s) - recombinant dna , biology , neuraminidase , human liver , beta (programming language) , interferon , catabolism , alpha interferon , alpha (finance) , virology , biochemistry , metabolism , in vitro , virus , gene , medicine , construct validity , nursing , patient satisfaction , computer science , programming language
The susceptibility of human leukocyte (alpha), fibroblast (beta) and recombinant alpha-2-interferons to clearance by the isolated and perfused rabbit liver has been evaluated. Human leukocyte and recombinant alpha-2-interferons were stable and their initial levels were maintained in the perfusate even if they had been treated with neuraminidase, thus suggesting that alpha-interferons have no exposed sugars recognizable by hepatic binding proteins. On the other hand, native, and particularly desialylated human beta-interferon, underwent marked hepatic uptake confirming the importance of the liver as a catabolic site for glycosylated interferons.