Open AccessStudies on an Interferon-sensitive Mutant of Mengovirus: Effects on Host RNA and Protein Syntheses
Author(s) -
Fout Gs,
Simon Eh
Publication year - 1981
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-52-2-391
Subject(s) - interferon , biology , vaccinia , mutant , virology , rna , host (biology) , virus , antiviral protein , protein biosynthesis , microbiology and biotechnology , genetics , gene , recombinant dna
Interferon induces an activity which strongly inhibits the growth of is-1, an interferon-response mutant of mengovirus. This activity is not expressed in protected cells infected with either is+ (the wild-type parent) or vaccinia virus, or in cells infected with is-1 in the presence of actinomycin D. A failure of is-1 to shut off host RNA and/or protein synthesis could explain these observations. The present paper, however, shows that is-1 and is+ are equally effective in suppressing host synthesis, and suggests that is+ actively inhibits the interferon-mediated activity directed against is-1.