Open AccessVaricella-Zoster Virus Transformation of Hamster Embryo Cells
Author(s) -
Lawrence D. Gelb,
John J. Huang,
Wanda Wellinghoff
Publication year - 1980
Publication title -
journal of general virology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-51-1-171
Subject(s) - virology , hamster , biology , virus , immunofluorescence , embryo , antigen , antibody , transformation (genetics) , immunology , microbiology and biotechnology , genetics , gene
Varicella-zoster virus infection of primary hamster embryo cells resulted in oncogenic transformation. These transformed cells exhibited virus-specific antigens by immunofluorescence and developed surface Fc receptors. They induced aggressive fibrosarcomas when injected into inbred hamsters. The tumour-bearing hamsters develop antibodies to varicella-zoster antigens.