Open AccessA Marsupial Oncovirus?
Author(s) -
R. C. Hamilton,
A. MacGregor,
David Pye
Publication year - 1979
Publication title -
journal of general virology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-44-2-535
Subject(s) - biology , cytoplasm , golgi apparatus , marsupial , nucleus , vacuole , nucleoid , cell , microbiology and biotechnology , virology , cell membrane , zoology , genetics , escherichia coli , gene
A virus-like particle was observed in two continuous cell lines derived from the marsupial Sminthopsis crassicaudata (Fat-tailed Dunnart). The development of the particle was similar to the development of D-type oncoviruses. Initially, a crescentof nucleoid material was observed near the nucleus in the region of the Golgi apparatus. This crescent developed into a doughnut-shaped-A-type particle which migrated through the cytoplasm towards the cell membrane where it budded either into a smooth membrane cytoplasmic vacuole or from the cell membrane. Only enveloped A-type particles were observed; no mature B-type, C-type or D-type particles were detected.