Open AccessRibonuclease Activity of Preparations of Human Lymphoblastoid Interferon
Author(s) -
Timothy P. Karpetsky,
Richard A. Winchurch,
C.J. Burman,
K. H. Fantes
Publication year - 1979
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-44-1-241
Subject(s) - ribonuclease , lymphoblast , interferon , biology , virology , microbiology and biotechnology , rna , biochemistry , cell culture , genetics , gene
Crude human lymphoblastoid interferon has less ribonuclease activity than equivalent primary leukocyte interferon and ribonuclease was eliminated when it was purified. The methods used differed from those that had failed to eliminate similar activity from leukocyte interferon. This result makes it unlikely that exogenous ribonuclease plays a major role in the antiviral action of interferon preparations.