Open AccessInhibition of a Complete Replication Cycle of Human Cytomegalovirus in Actinomycin Pre-treated Cells
Author(s) -
M.P. Landini,
Monica Musiani,
Marialuisa Zerbini,
Elisabetta Falcieri,
M. La Plaça
Publication year - 1979
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-42-2-423
Subject(s) - biology , virology , vaccinia , herpes simplex virus , virus , human cytomegalovirus , viral replication , poliovirus , transcription (linguistics) , embryo , dna replication , dna , gene , genetics , recombinant dna , linguistics , philosophy
The study of human cytomegalovirus (HCMV) in cultures of human embryo lung fibroblasts, pre-treated with actinomycin D, has shown that under these conditions the virus infection does not proceed beyond the 'early' events of the virus replication cycle. In the same experimental conditions the growth of poliovirus type I, vaccinia virus and herpes simplex type I virus, was completely unaffected. These results suggest that the complete HCMV replication cycle requires some cellular function(s) between early transcription of the input virus genome and virus DNA synthesis.