Open AccessThe ocr Gene Function of Bacterial Viruses T3 and T7 Prevents Host-controlled Modification
Author(s) -
Detlev H. Krüger,
Gabriel Gola,
Ilona Weisshuhn,
Sigrid Hansen
Publication year - 1978
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-41-1-189
Subject(s) - biology , virology , function (biology) , host (biology) , gene , microbiology and biotechnology , genetics
On pre-infection of the host Escherichia coli B with u.v.-inactivated T3 or T7 phage able to express their early genes (like 0.3), B-specific modification of superinfecting, successfully multiplying viruses does not take place. The ocr gene function (gene 0.3) of T3 and T7 not only prevents host-specific DNA restriction but also modification, probably by inhibiting the same late step in the interaction between the restriction enzyme and DNA.