Open AccessMetabolism of Myoinositol in Avian and Mammalian Cells Infected with Naked and Enveloped DNA and RNA Viruses
Author(s) -
Heino Diringer,
Wulf R. Willems,
R. Rott
Publication year - 1978
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-40-2-471
Subject(s) - biology , inositol , virology , phosphatidylinositol , viral envelope , virus , rna , metabolism , dna , biochemistry , gene , signal transduction , receptor
The uptake of 3H-inositol into the pool of free inositol and its incorporation into the lipid phosphatidylinositol have been studied in various avian and mammalian cells infected by different viruses. In all the virus-cell systems investigated, virus infection results in a drastically reduced amount of free 3H-inositol about 3 to 5 h post-infection, demonstrable in the infected cells as compared to the mock-infected controls. In contrast, the incorporation of 3H-inositol into lipid can be enhanced, reduced, or not influenced at all, depending on the virus-cell system under observation.