Open AccessEffects of Ouabain on the Anticellular and Antiviral Activities of Human and Mouse Interferon
Author(s) -
T. Kuwata,
Akira Fuse,
Naoko Morinaga
Publication year - 1977
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-34-3-537
Subject(s) - ouabain , interferon , biology , virology , embryonic stem cell , pharmacology , chemistry , sodium , biochemistry , organic chemistry , gene
When transformed human embryonic cells, RSa and RSb, were treated for 48 h with both 10(-7) M-ouabain and 1000 units/ml of human leucocyte inteferon, there was an additive suppression of cell growth. In contrast, the antiviral action of the human interferon was inhibited by this concentration of ouabain. Similar effects of combined treatment with interferon and ouabain were found with IFr cells (which are relatively resistant to the anticellular effect of interferon), and with mouse cells of the K3b line.