Open AccessPolykaryocytosis Induced by Certain Arboviruses in Monolayers of BHK-21-528 Cells
Author(s) -
Noboru Ueba,
Tomoaki Kimura
Publication year - 1977
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-34-2-369
Subject(s) - virology , biology , encephalitis , giant cell , dengue fever , cell fusion , chikungunya , virus , arbovirus , clone (java method) , alphavirus , cell culture , genetics , dna
Multinucleated giant cell formation in a clone of BHK-21 cells, BHK-21-528, was tested with certain arboviruses. Eleven out of 19 viruses tested, Chikungunya, Getah, Sagiyama, Sindbis, Western equine encephalitis, St. Louis encephalitis, Japanese encephalitis, West Nile, Bunyamwera, Germiston and California encephalitis virus induced cell fusion after infection. All cases where giant cells were observed during the experiments, involved the B type cell fusion (fusion from within).