Open AccessThymus Dependence of Rabies Vaccine
Author(s) -
G. S. Turner
Publication year - 1976
Publication title -
journal of general virology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-33-3-535
Subject(s) - rabies , virology , biology , antigen , rabies vaccine , antibody , neutralizing antibody , antibody response , immune system , duck embryo vaccine , immunology , inoculation , rabies virus
Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.