Open AccessEffects of Interferon on the Human Clonal Cell Line, RSa: Inhibition of Macromolecular Synthesis
Author(s) -
Akira Fuse,
T. Kuwata
Publication year - 1976
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-33-1-17
Subject(s) - biology , interferon , cell division , cell culture , dna synthesis , virology , dna , cell , microbiology and biotechnology , genetics
Multiplication of the human clonal cell line, RSa, is completely inhibited by human leukocyte interferon preparations. Synthesis of DNA and protein is markedly reduced in these cells in proportion to the concentration of interferon applied. Interferon treatment leads to accumulation of cells of an epithelial morphology which do not enter the division cycle. It is suggested that the growth inhibitory effects of interferon on RSa cells may result from these effects.