Open AccessVenezuelan Equine Encephalomyelitis Virus (VEEV): Strain Differentiation and Specification of Virulence Markers
Author(s) -
R. Walder,
C. J. Bradish
Publication year - 1975
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-26-3-265
Subject(s) - biology , virology , virulence , strain (injury) , virus strain , virus , encephalomyelitis , venezuelan equine encephalitis virus , alphavirus , genetics , immunology , multiple sclerosis , gene , anatomy
Fourteen strains of VEEV of diverse origin and antigenicity were classified into five virulence categories according to their efficiency of infection and nature of response in mice. Mice of ages up to 30 days represented distinct levels of responsiveness and were suitable for the differentiation of VEEV strains of highest to lowest virulence. Stepwise changes with age of the susceptibility or responsiveness of mice appeared to determined the type of response as predominantly lethal (D), dual or intermediate (DP) or protective (P).