Open AccessLong-term potentiation and the ageing brain
Author(s) -
Carol A. Barnes
Publication year - 2003
Publication title -
philosophical transactions - royal society. biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.753
H-Index - 272
eISSN - 1471-2970
pISSN - 0962-8436
DOI - 10.1098/rstb.2002.1244
Subject(s) - long term potentiation , neuroscience , ageing , hippocampus , synaptic plasticity , hippocampal formation , metaplasticity , neuroplasticity , memory consolidation , psychology , biology , biochemistry , genetics , receptor
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.