Open AccessMultiscale analysis of the randomization limits of the chromosomal gene organization between Lepidoptera and Diptera
Author(s) -
José M. Ranz,
Pablo M. González,
Ryan N. Su,
Sarah J. Bedford,
Cei AbreuGoodger,
Therese A. Markow
Publication year - 2022
Publication title -
proceedings - royal society. biological sciences/proceedings - royal society. biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.342
H-Index - 253
eISSN - 1471-2954
pISSN - 0962-8452
DOI - 10.1098/rspb.2021.2183
Subject(s) - biology , danaus , genome , genetics , lepidoptera genitalia , drosophila melanogaster , evolutionary biology , most recent common ancestor , ancestor , gene , chromosome , phylogenetic tree , ploidy , ecology , history , archaeology
How chromosome gene organization and gene content evolve among distantly related and structurally malleable genomes remains unresolved. This is particularly the case when considering different insect orders. We have compared the highly contiguous genome assemblies of the lepidopteranDanaus plexippus and the dipteranDrosophila melanogaster, which shared a common ancestor around 290 Ma. The gene content of 23 out of 30D. plexippus chromosomes was significantly associated with one or two of the six chromosomal elements of theDrosophila genome, denoting common ancestry. Despite the phylogenetic distance, 9.6% of the 1-to-1 orthologues still reside within the same ancestral genome neighbourhood. Furthermore, the comparisonD. plexippus–Bombyx mori indicated that the rates of chromosome repatterning are lower in Lepidoptera than in Diptera, although still within the same order of magnitude. Concordantly, 14 developmental gene clusters showed a higher tendency to retain full or partial clustering inD. plexippus, further supporting that the physical association between the SuperHox and NK clusters existed in the ancestral bilaterian. Our results illuminate the scope and limits of the evolution of the gene organization and content of the ancestral chromosomes to the Lepidoptera and Diptera while helping reconstruct portions of the genome in their most recent common ancestor.