Open AccessColorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles
Author(s) -
Daim Asif Raja,
Fazeelah Munir,
Muhammad Raza Shah,
Muhammad Iqbal Bhanger,
Muhammad Imran Malik
Publication year - 2021
Publication title -
royal society open science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.84
H-Index - 51
ISSN - 2054-5703
DOI - 10.1098/rsos.210185
Subject(s) - colloidal gold , cephradine , zeta potential , detection limit , surface plasmon resonance , nanoparticle , materials science , drug detection , fourier transform infrared spectroscopy , nanotechnology , spectrophotometry , chloroauric acid , nuclear chemistry , chemistry , chromatography , chemical engineering , biochemistry , cephalosporin , engineering , antibiotics
The development of metal nanoparticle-based facile colorimetric assays for drugs and insecticides is an emerging area of current scientific research. In the present work, polypropylene glycol was used for stabilization of gold nanoparticles (AuNPs) in a simple one-pot two-phase process and subsequently employed it for the specific detection of cephradine (CPH). The characterization of the prepared PPG-AuNPs was conducted through various analytical techniques such as UV-visible spectrophotometry, Fourier transform infrared spectroscopy, atomic force microscopy (AFM), zeta potential and zetasizer techniques. As the major target of the study, the stabilized PPG-AuNPs were employed for colorimetric detection of CPH and other drugs. Typical wine-red colour of PPG-AuNPs disappeared immediately and surface plasmon resonance band quenched by addition of CPH in the presence of several other interferents (drugs and salts) and in real samples. PPG-AuNPs permitted efficient, selective, reliable and rapid determination in a concentration range of 0.01–120 mM with a detection limit (LoD) of 11.0 mM. The developed sensor has the potential to be used for fast scanning of pharmaceutical formulations for quantification of CPH at production facilities.