Open AccessThe multifaceted role of lemur tyrosine kinase 3 in health and disease
Author(s) -
Angeliki Ditsiou,
Teresa Gagliano,
Mark E. Samuels,
Viviana Vella,
Christos M. Tolias,
Georgios Giamas
Publication year - 2021
Publication title -
open biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.078
H-Index - 53
ISSN - 2046-2441
DOI - 10.1098/rsob.210218
Subject(s) - biology , disease , receptor tyrosine kinase , function (biology) , signal transduction , tyrosine kinase , bioinformatics , computational biology , neuroscience , microbiology and biotechnology , medicine
In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.