Open AccessRegulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
Author(s) -
Xinyi Wang,
Ting Liu,
Yifei Huang,
Yifeng Dai,
Hui Lin
Publication year - 2021
Publication title -
open biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.078
H-Index - 53
ISSN - 2046-2441
DOI - 10.1098/rsob.210043
Subject(s) - biology , sumo protein , myofibroblast , fibrosis , transforming growth factor , hedgehog signaling pathway , microbiology and biotechnology , transcription factor , transforming growth factor beta , signal transduction , epithelial–mesenchymal transition , cancer research , gene , genetics , downregulation and upregulation , ubiquitin , medicine
Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this process, with the transforming growth factor-β (TGF-β) signalling pathway playing a central role. TGF-β regulates the generation of myofibroblasts and the epithelial–mesenchymal transition by regulating transcription and translation of downstream genes and precisely regulating fibrogenesis. The TGF-β signalling pathway can be modulated by various post-translational modifications, of which SUMOylation has been shown to play a key role. In this review, we focus on the function of SUMOylation in canonical and non-canonical TGF-β signalling and its role in fibrosis, providing promising therapeutic strategies for fibrosis.