Driving forces in the origins of life | Zendy

Ken A. Dill | Zendy; Luca Agozzino | Zendy

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Driving forces in the origins of life

Author(s) -

Ken A. Dill,

Luca Agozzino

Publication year - 2021

Publication title -

open biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.078

H-Index - 53

ISSN - 2046-2441

DOI - 10.1098/rsob.200324

Subject(s) - biology , heritability , abiogenesis , evolutionary biology , prebiotic , biological evolution , chemical space , sequence (biology) , computational biology , genetics , bioinformatics , drug discovery

What were the physico-chemical forces that drove the origins of life? We discuss four major prebiotic ‘discoveries’: persistent sampling of chemical reaction space; sequence-encodable foldable catalysts; assembly of functional pathways; and encapsulation and heritability. We describe how a ‘proteins-first’ world gives plausible mechanisms. We note the importance of hydrophobic and polar compositions of matter in these advances.

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