Open AccessNew insights and perspectives on the genetics of obsessive-compulsive disorder
Author(s) -
Gwyneth Zai,
Csaba Barta,
Daniëlle C. Cath,
Valsamma Eapen,
Daniel Geller,
Edna Grünblatt
Publication year - 2019
Publication title -
psychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.661
H-Index - 60
eISSN - 1473-5873
pISSN - 0955-8829
DOI - 10.1097/ypg.0000000000000230
Subject(s) - genome wide association study , psychiatric genetics , obsessive compulsive , psychiatry , perspective (graphical) , twin study , genetic association , molecular genetics , psychology , medicine , genetics , biology , gene , schizophrenia (object oriented programming) , heritability , single nucleotide polymorphism , genotype , artificial intelligence , computer science
Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.