Open AccessBrain vasculature disturbance in schizophrenia
Author(s) -
Sofía Puvogel,
Verónica Palma,
Iris Sommer
Publication year - 2022
Publication title -
current opinion in psychiatry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.66
H-Index - 90
eISSN - 1473-6578
pISSN - 0951-7367
DOI - 10.1097/yco.0000000000000789
Subject(s) - endothelium , blood–brain barrier , medicine , inflammation , hypoxia (environmental) , cerebral blood flow , neuroscience , cerebral perfusion pressure , antipsychotic , neuroinflammation , schizophrenia (object oriented programming) , psychology , central nervous system , psychiatry , chemistry , organic chemistry , oxygen
The vascular hypothesis of schizophrenia (SZ) postulates that brain endothelial dysfunction contributes to brain pathophysiology. This review discusses recent evidence for and against this hypothesis, including data related to blood-brain barrier (BBB), brain endothelium, and brain blood supply, to provide a critical weighed update.