Open AccessAbnormal synaptic pruning during adolescence underlying the development of psychotic disorders
Author(s) -
Monique Germann,
Sanne Brederoo,
Iris Sommer
Publication year - 2021
Publication title -
current opinion in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.66
H-Index - 90
eISSN - 1473-6578
pISSN - 0951-7367
DOI - 10.1097/yco.0000000000000696
Subject(s) - synaptic pruning , schizophrenia (object oriented programming) , neuroscience , psychosis , pruning , cognition , disease , psychology , medicine , microglia , psychiatry , biology , inflammation , agronomy
Excessive synaptic pruning has first been suggested by Irwin Feinberg (1982) as an important pillar in the pathophysiology in schizophrenia (SCZ). This article reviews recent developments highlighting factors implicated in aberrant synaptic pruning and its contribution to disease onset and emergence of cognitive symptoms in SCZ. Unraveling these factors provides new insights for potential prevention and treatment strategies for psychotic disorders.