Open AccessLow glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats
Author(s) -
Leanne Groban,
Hao Wang,
Frederico Sander Mansur Machado,
Aaron J. Trask,
Stephen B. Kritchevsky,
Carlos M. Ferrario,
Debra I. Diz
Publication year - 2012
Publication title -
cardiovascular endocrinology
Language(s) - English
Resource type - Journals
ISSN - 2162-688X
DOI - 10.1097/xce.0b013e32835a2159
Subject(s) - medicine , endocrinology , diastole , ventricle , cardiac function curve , angiotensin ii , renin–angiotensin system , heart failure , receptor , blood pressure
Long-term systemic blockade of the renin-angiotensin system (RAS) with either an angiotensin (Ang) II type 1 receptor antagonist or an angiotensin-converting enzyme inhibitor attenuates age-related cardiac remodeling and oxidative damage, and improves myocardial relaxation. However, the role of the brain RAS in mediating the development of diastolic dysfunction during aging is not known. We hypothesized that low brain RAS protects against the development of age-related diastolic dysfunction and left ventricular remodeling.